Neurobiology of Sleep-Wakefulness Cycle 2(1): 1-5, 2002
Printed in Georgia. All rights reserved.
2002 NSWC

HIGH DOSES ETHANOL EFFECTS ON THE STRUCTURE OF SLEEP-WAKEFULNESS CYCLE IN RATS

M. Gogichadze, N. Omiadze, O. Mchedlidze

Department of Neurobiology of Sleep-Wakefulness Cycle, I.S. Beritashvili Institute of Physiology, Georgian Academy of Sciences, Tbilisi

Accepted in revised form 27 February 2002; recieved 14 December 2001.

Summary

The effects of high doses of Ethanol on the some patterns of the structure of sleep-wakefulness cycle (SW-C) in rats were studied under conditions of chronic experiments. The analysis of obtained date gave evidence that amplitude of electrical activity of cortical areas after 15-30 min of administration of high dose (4,5g/kg) is suppressed to EEG-depression, muscle relaxation and spinal reflexes inhibition are observed as well. During EEG-depression the normal SW-C has not been generated. All phases are reduced in the successive SW-C due to EEG-depression. The disturbances of SW-C remained on another day. At dose 2,25 g/kg less EEG-effects and smaller disturbances of SW-C are observed.

Key Words: Ethanol, EEG-depression, sleep-wakefulness cycle.


Correspondence: Gogichadze Maria, Dr.,
Department of Neurobiology of Sleep-Wakefulness Cycle,
I.S. Beritashvili Institute of Physiology, Georgian Academy of Sciences,
14, L. Gotua str., Tbilisi, 380060, Georgia.
E-mail: nswc@neurobiology.ge